Molecular and cellular biochemistry, 2014-10, Vol.395 (1-2), p.211-219
2014
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Details
- Autor(en) / Beteiligte
- Titel
- TRAF4 participates in Wnt/β-catenin signaling in breast cancer by upregulating β-catenin and mediating its translocation to the nucleus
- Ist Teil von
- Molecular and cellular biochemistry, 2014-10, Vol.395 (1-2), p.211-219
- Ort / Verlag
- Boston: Springer US
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Tumor necrosis factor receptor-associated factor 4 (TRAF4) is upregulated in various subtypes of breast cancers and cell lines; however, the precise functions of TRAF4 are poorly understood. Our objective was to investigate its relationship with β-catenin. TRAF4 participates in several signaling pathways, such as NF-κB and JNK signaling pathways. In this study, we identified β-catenin as a TRAF4-binding protein, have shown that TRAF4 enhanced expression of β-catenin, and found that TRAF4 mediated the translocation of β-catenin from the cytoplasm to the nucleus, thereby facilitating activation of the Wnt signaling pathway in breast cancer.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0300-8177eISSN: 1573-4919DOI: 10.1007/s11010-014-2127-yTitel-ID: cdi_proquest_miscellaneous_1553327532
- Format
- –
- Schlagworte
- Active Transport, Cell Nucleus, beta Catenin - metabolism, Biochemistry, Biomedical and Life Sciences, Breast cancer, Breast Neoplasms - genetics, Breast Neoplasms - metabolism, Cardiology, Cell Line, Tumor, Cell Nucleus - metabolism, Female, Gene Expression Regulation, Neoplastic, Humans, Life Sciences, MCF-7 Cells, Medical Biochemistry, Oncology, Protein binding, TNF Receptor-Associated Factor 4 - genetics, TNF Receptor-Associated Factor 4 - metabolism, Tumor necrosis factor, Up-Regulation, Wnt Signaling Pathway