Details

Autor(en) / Beteiligte

• van Tiel, Jasper
• Kotek, Gyula
• Reijman, Max
• Bos, Pieter K.
• Bron, Esther E.
• Klein, Stefan
• Verhaar, Jan A. N.
• Krestin, Gabriel P.
• Weinans, Harrie
• Oei, Edwin H. G.

Titel

Delayed gadolinium-enhanced MRI of the meniscus (dGEMRIM) in patients with knee osteoarthritis: relation with meniscal degeneration on conventional MRI, reproducibility, and correlation with dGEMRIC

Ist Teil von

• European radiology, 2014-09, Vol.24 (9), p.2261-2270

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2014

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Objectives To assess (1) whether normal and degenerated menisci exhibit different T1 GD on delayed gadolinium-enhanced MRI of the meniscus (dGEMRIM), (2) the reproducibility of dGEMRIM and (3) the correlation between meniscus and cartilage T1 GD in knee osteoarthritis (OA) patients. Methods In 17 OA patients who underwent dGEMRIM twice within 7 days, meniscus and cartilage T1 GD was calculated. Meniscus pathology was evaluated on conventional MRI. T1 GD in normal and degenerated menisci were compared using a Student’s t -test. Reproducibility was assessed using ICCs. Pearson’s correlation was calculated between meniscus and cartilage T1 GD . Results A trend towards lower T1 GD in degenerated menisci (mean: 402 ms; 95 % CI: 359–444 ms) compared to normal menisci (mean: 448 ms; 95 % CI: 423–473 ms) was observed ( p  = 0.05). Meniscus T1 GD ICCs were 0.85–0.90. The correlation between meniscus and cartilage T1 GD was moderate in the lateral ( r  = 0.52–0.75) and strong in the medial compartment ( r  = 0.78–0.94). Conclusions Our results show that degenerated menisci have a clear trend towards lower T1 GD compared to normal menisci. Since these results are highly reproducible, meniscus degeneration may be assessed within one delayed gadolinium-enhanced MRI simultaneously with cartilage. The strong correlation between meniscus and cartilage T1 GD suggests concomitant degeneration in both tissues in OA, but also suggests that dGEMRIC may not be regarded entirely as sulphated glycosaminoglycan specific. Key Points • dGEMRIM T1 GD can possibly be used to assess meniscal degeneration; • dGEMRIM yields highly reproducible meniscal T1 GD in early stage osteoarthritic patients; • Concomitant degeneration of cartilage and meniscus tissue occurs in early stage osteoarthritis; • dGEMRIC cannot be regarded as entirely sulphated glycosaminoglycan specific.