Details

Autor(en) / Beteiligte

• Prüßmann, Jasper
• Prüßmann, Wiebke
• Recke, Andreas
• Rentzsch, Kristin
• Juhl, David
• Henschler, Reinhard
• Müller, Susen
• Lamprecht, Peter
• Schmidt, Enno
• Csernok, Elena
• Görg, Siegfried
• Stöcker, Winfried
• Zillikens, Detlef
• Ibrahim, Saleh M.
• Ludwig, Ralf J.

Titel

Co-occurrence of autoantibodies in healthy blood donors

Ist Teil von

• Experimental dermatology, 2014-07, Vol.23 (7), p.519-521

Ort / Verlag

Denmark: Blackwell Publishing Ltd

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Autoimmune diseases are rare, but their incidence has increased over the past decades. Interestingly, the co‐occurrence of autoimmune diseases is well documented; however, data on the presence of more than one specific autoantibody in healthy individuals are not available. Here, we investigated the prevalence of several autoantibodies in a cohort of over 6000 healthy persons. While individual autoantibodies were rarely detected (i.e. ranging from 0.3% for ANCA to 4.6% for anti‐TPO), the cumulative prevalence of the tested autoantibodies was as high as 10%. Furthermore, our results demonstrate co‐occurrence of ANA with specific autoantibodies that target TPO, CCP and Dsg1/3, while ANCA and autoantibodies to PCA and BP180/BP230 were not more frequent in ANA‐positive compared to ANA‐negative samples. This indicates that shared and independent mechanisms influence loss of tolerance to distinct sets of self‐antigens.