Details

Autor(en) / Beteiligte

• Lee, H
• Kim, E.S
• Choi, C
• Seo, H
• Shin, M
• Bok, J.H
• Cho, J.E
• Kim, C.J
• Shin, J.W
• Kim, T.S
• Song, K.H
• Park, K.U
• Kim, B.I
• Kim, H.B

Titel

Outbreak among healthy newborns due to a new variant of USA300-related meticillin-resistant Staphylococcus aureus

Ist Teil von

• The Journal of hospital infection, 2014-07, Vol.87 (3), p.145-151

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Summary Background The prevalence of community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA) is increasing throughout the world and is an important cause of skin and soft tissue infection (SSTI) in children and neonates. Aim To describe the successful control of an outbreak caused by a new strain of CA-MRSA in a newborn nursery. Methods The investigation of the outbreak in July 2012 is reported with the control measures taken. Molecular typing of the MRSA isolates was performed. Findings An outbreak of SSTI caused by CA-MRSA occurred in a newborn nursery. Six neonates were infected in a one-month period [infection rate: 8.5% (6/71)]. A new variant of CA-MRSA was responsible, which was characterized as USA300-related, Panton–Valentine Leucocidin (PVL) positive, arginine catabolic mobile element (ACME) negative, sequence type 8 (ST8), staphylococcal cassette chromosome mec (SCC mec ) type IVa, agr type I and spa type t008. The outbreak among term neonates followed a rapid transmission pattern and was successfully controlled by implementing various outbreak control measures, including universal chlorhexidine bathing. Conclusion This is the first report of a hospital outbreak caused by a USA300-related CA-MRSA clone in Korea. Early recognition and reinforcement of infection control measures are important in decreasing transmission of CA-MRSA in a hospital setting.