Details

Autor(en) / Beteiligte

• Mangan, Bozgana A
• Dunne, Margaret R
• O'Reilly, Vincent P
• Dunne, Padraic J
• Exley, Mark A
• O'Shea, Donal
• Scotet, Emmanuel
• Hogan, Andrew E
• Doherty, Derek G

Titel

Cutting Edge: CD1d Restriction and Th1/Th2/Th17 Cytokine Secretion by Human V delta 3 T Cells

Ist Teil von

• The Journal of immunology (1950), 2013-07, Vol.191 (1), p.30-34

Erscheinungsjahr

2013

Quelle

Elektronische Zeitschriftenbibliothek (Open access)

Beschreibungen/Notizen

• Human gamma delta T cells expressing the V delta 3 TCR make up a minor lymphocyte subset in blood but are enriched in liver and in patients with some chronic viral infections and leukemias. We analyzed the frequencies, phenotypes, restriction elements, and functions of fresh and expanded peripheral blood V delta 3 T cells. V delta 3 T cells accounted for similar to 0.2% of circulating T cells, included CD4+, CD8+, and CD4-CD8- subsets, and variably expressed CD56, CD161, HLA-DR, and NKG2D but neither NKG2A nor NKG2C. V delta 3 T cells were sorted and expanded by mitogen stimulation in the presence of IL-2. Expanded V delta 3 T cells recognized CD1d but not CD1a, CD1b, or CD1c. Upon activation, they killed CD1d+ target cells, released Th1, Th2, and Th17 cytokines, and induced maturation of dendritic cells into APCs. Thus, V delta 3 T cells are glycolipid-reactive T cells with distinct Ag specificities but functional similarities to NKT cells.