Details

Autor(en) / Beteiligte

• Sedgwick, Paul
• Spiehler, Vina R.
• Lowe, D. Russell

Titel

Toxicological Findings in Amoxapine Overdose

Ist Teil von

• Journal of analytical toxicology, 1982-03, Vol.6 (2), p.82-84

Ort / Verlag

England: Oxford University Press

Erscheinungsjahr

1982

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Tissue concentrations of amoxapine, a new antidepressant with antipsychotic properties, were determined in two cases in which amoxapine was taken in overdose. Two extractions and GLC procedures, UV spectra, and TLC properties of amoxapine are described. The concentrations of amoxapine are described. The concentrations of amoxapine in brain tissue (52 µg/g and 53.2 µg/g) were about equal to concentrations found in liver (77 µg/g and 50 µg/g) and higher than blood concentrations (6 µg/mL and 1.5 µg/mL). The two metabolites of amoxapine, 8-hydroxyamoxapine and 7-hydroxyamoxapine, were not detected by TLC or GLC.