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Different exosome cargo from plasma/bronchoalveolar lavage in non-small-cell lung cancer
Genes chromosomes & cancer, 2014-09, Vol.53 (9), p.713-724
Rodríguez, Marta
Silva, Javier
López-Alfonso, Ana
López-Muñiz, María Belen
Peña, Cristina
Domínguez, Gemma
García, Jose Miguel
López-Gónzalez, Ana
Méndez, Miriam
Provencio, Mariano
García, Vanesa
Bonilla, Félix
2014
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Rodríguez, Marta
Silva, Javier
López-Alfonso, Ana
López-Muñiz, María Belen
Peña, Cristina
Domínguez, Gemma
García, Jose Miguel
López-Gónzalez, Ana
Méndez, Miriam
Provencio, Mariano
García, Vanesa
Bonilla, Félix
Titel
Different exosome cargo from plasma/bronchoalveolar lavage in non-small-cell lung cancer
Ist Teil von
Genes chromosomes & cancer, 2014-09, Vol.53 (9), p.713-724
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2014
Quelle
Wiley Online Library All Journals
Beschreibungen/Notizen
Tumor‐derived exosomes mediate tumorigenesis by facilitating tumor growth, metastasis, development of drug resistance, and immunosuppression. However, little is known about the exosomes isolated from bronchoalveolar lavage (BAL) in patients with lung neoplasm. Exosomes isolated in plasma and BAL from 30 and 75 patients with tumor and nontumor pathology were quantified by acetylcholinesterase activity and characterized by Western Blot, Electron Microscopy, and Nanoparticle Tracking Analysis. Differences in exosome cargo were analyzed by miRNA quantitative PCR in pooled samples and validated in a second series of patients. More exosomes were detected in plasma than in BAL in both groups (P < 0.001). The most miRNAs evaluated by PCR array were detected in tumor plasma, tumor BAL, and nontumor BAL pools, but only 56% were detected in the nontumor plasma pool. Comparing the top miRNAs with the highest levels detected in each pool, we found close homology only between the BAL samples of the two pathologies. In tumor plasma, we found a higher percentage of miRNAs with increased levels than in tumor BAL or in nontumor plasma. The data reveal differences between BAL and plasma exosome amount and miRNA content. © 2014 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1045-2257
eISSN: 1098-2264
DOI: 10.1002/gcc.22181
Titel-ID: cdi_proquest_miscellaneous_1547865807
Format
–
Schlagworte
Adenocarcinoma - blood
,
Adenocarcinoma - chemistry
,
Adenocarcinoma - pathology
,
Adolescent
,
Adult
,
Aged
,
Aged, 80 and over
,
Blood - metabolism
,
Bronchoalveolar Lavage Fluid - chemistry
,
Bronchoalveolar Lavage Fluid - cytology
,
Carcinoma, Non-Small-Cell Lung - blood
,
Carcinoma, Non-Small-Cell Lung - chemistry
,
Carcinoma, Non-Small-Cell Lung - pathology
,
Carcinoma, Squamous Cell - blood
,
Carcinoma, Squamous Cell - chemistry
,
Carcinoma, Squamous Cell - pathology
,
Exosomes - metabolism
,
Female
,
Humans
,
Lung cancer
,
Lung Neoplasms - blood
,
Lung Neoplasms - chemistry
,
Lung Neoplasms - pathology
,
Male
,
MicroRNAs - metabolism
,
Middle Aged
,
Young Adult
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