Details

Autor(en) / Beteiligte

• Korgavkar, Kaveri
• Firoz, Elnaz F.
• Xiong, Michael
• Lew, Robert
• Marcolivio, Kimberly
• Burnside, Nancy
• Dyer, Robert
• Weinstock, Martin A.

Titel

Measuring the Severity of Topical 5-Fluorouracil Toxicity

Ist Teil von

• Journal of cutaneous medicine and surgery, 2014-07, Vol.18 (4), p.229-235

Ort / Verlag

Los Angeles, CA: SAGE Publications

Erscheinungsjahr

2014

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background: Topical 5% 5-fluorouracil (5-FU) is known to cause toxicity, such as erythema, pain, and crusting/erosions. Objectives: We sought to develop a scale to measure this toxicity and test the scale for reliability. Methods: A scale was developed involving four parameters: erythema severity, percentage of face involved in erythema, crusting/erosions severity, and percentage of face involved in crusting/erosions. Thirteen raters graded 99 sets of photographs from the Veterans Affairs Keratinocyte Carcinoma Chemoprevention (VAKCC) Trial using these parameters. Results: Intraclass correlation overall for 13 raters was 0.82 (95% CI 0.77–0.86). There was no statistically significant trend in reliability by level of training in dermatology. Conclusions: This scale is a reliable method of evaluating the severity of toxicity from topical 5-fluorouracil and can be used by dermatologists and nondermatologists alike.