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Dysideanones A–C, Unusual Sesquiterpene Quinones from the South China Sea Sponge Dysidea avara
Ist Teil von
Journal of natural products (Washington, D.C.), 2014-02, Vol.77 (2), p.346-350
Ort / Verlag
United States: American Chemical Society and American Society of Pharmacognosy
Erscheinungsjahr
2014
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Dysideanones A–C (1–3), three unusual sesquiterpene quinones with unprecedented carbon skeletons, were isolated from the South China Sea sponge Dysidea avara. Their structures including absolute configurations were determined by a combination of spectroscopic analyses and calculated ECD spectra. Within the sesquiterpene quinone structures, dysideanones A (1) and B (2) share an unprecedented 6/6/6/6-fused tetracyclic carbon skeleton, while dysideanone C (3) possesses an unusual 6/6/5/6-fused tetracyclic core. Dysideanone B (2) showed cytotoxicity against two human cancer cell lines, HeLa and HepG2, with IC50 values of 7.1 and 9.4 μM, respectively.