Details

Autor(en) / Beteiligte

• Ott, Patrick A., MD, PhD
• Fritsch, Edward F., PhD
• Wu, Catherine J., MD
• Dranoff, Glenn, MD

Titel

Vaccines and Melanoma

Ist Teil von

• Hematology/oncology clinics of North America, 2014-06, Vol.28 (3), p.559-569

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2014

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The potential for therapeutic efficacy of a melanoma vaccine has been evident preclinically for many years. In melanoma patients, vaccines have resulted in the induction of immune responses, although clinical benefit has not been clearly documented. The recent achievements with immune-checkpoint blockade have shown that immunotherapy can be a powerful tool in cancer therapy. With increased understanding of tumor immunity, the limitations of previous cancer vaccination approaches have become evident. Rapid progress in technologies that enable better vaccine design raise the expectation that these limitations can be overcome, thus leading to a clinically effective melanoma vaccine in the near future.