Details

Autor(en) / Beteiligte

• Yang, Tao, MD
• Li, Zhen-Nan, MD
• Chen, Guo, MD
• Gu, Qing, MD
• Ni, Xin-Hai, MD
• Zhao, Zhi-Hui, MD
• Ye, Jue, MB
• Meng, Xian-Min, PhD
• Liu, Zhi-Hong, MD
• Xiong, Chang-Ming, MD
• He, Jian-Guo, MD

Titel

Increased levels of plasma CXC-Chemokine Ligand 10, 12 and 16 are associated with right ventricular function in patients with idiopathic pulmonary arterial hypertension

Ist Teil von

• Heart & lung, 2014-07, Vol.43 (4), p.322-327

Ort / Verlag

United States: Mosby, Inc

Erscheinungsjahr

2014

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Abstract Objective To investigate plasma levels of CXC-Chemokine Ligand 10 (CXCL10), CXC-Chemokine Ligand 12 (CXCL12) and CXC-Chemokine Ligand 16 (CXCL16) in patients with idiopathic pulmonary arterial hypertension (IPAH). Methods Plasma levels of biomarkers were measured by enzyme-linked immunosorbent assay in 61 patients with IPAH and 20 healthy volunteers. Results Plasma CXCL10, CXCL12 and CXCL16 concentrations were increased significantly in IPAH patients compared with controls, and significantly correlated with N-terminal pro-brain natriuretic peptide, tricuspid annulus plane systolic excursion and right ventricular ejection fraction. Conclusions Increased levels of CXCL10, CXCL12 and CXCL16 are associated with right ventricular dysfunction in patients with IPAH.