Trends in immunology, 2014-06, Vol.35 (6), p.253-261
2014
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Details
- Autor(en) / Beteiligte
- Titel
- Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome
- Ist Teil von
- Trends in immunology, 2014-06, Vol.35 (6), p.253-261
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • The NLRP3 inflammasome is activated by mitochondrial destabilization and dysfunction. • Recognition of mtDNA and externalized cardiolipin by the NLRP3 inflammasome may be direct. • Ca2+ is mobilized in many settings of NLRP3 inflammasome activation. • Intercepting Ca2+ mobilization inhibits inflammasome activation. • Ca2+ may trigger mitochondrial destabilization leading to NLRP3 inflammasome activation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1471-4906eISSN: 1471-4981DOI: 10.1016/j.it.2014.02.007Titel-ID: cdi_proquest_miscellaneous_1543682273
- Format
- –
- Schlagworte
- Allergy and Immunology, Animals, Apoptosis, Calcium, Calcium Signaling, Calcium-Binding Proteins - genetics, Calcium-Binding Proteins - metabolism, Humans, Inflammasomes - genetics, Inflammasomes - metabolism, Kinases, Metabolic disorders, Mitochondria - metabolism, mitochondrial damage, mitochondrial destabilization, NLRP3 inflammasome, Rodents