Nutrition (Burbank, Los Angeles County, Calif.), 2014-07, Vol.30 (7), p.915-919
2014
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- Autor(en) / Beteiligte
- Titel
- Resveratrol attenuates hepatic steatosis in high-fat fed mice by decreasing lipogenesis and inflammation
- Ist Teil von
- Nutrition (Burbank, Los Angeles County, Calif.), 2014-07, Vol.30 (7), p.915-919
- Ort / Verlag
- New York, NY: Elsevier Inc
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Abstract Objective Resveratrol (RSV) is the most studied natural compound that activates sirtuins, which produce beneficial metabolic effects on lipid and glucose metabolism. The aim of the present study was to investigate the role of resveratrol in preventing nonalcoholic fatty liver disease (NAFLD) and expression of liver inflammatory markers in mice treated with a high-fat diet. Methods and procedures Eighteen male mice were divided into three groups and fed for 60 d with a standard diet (ST), high-fat diet (HFD), or high-fat diet plus resveratrol (HFD + RSV, 30 mg/kg/d). Body weight, food intake, and serum total cholesterol, triacylglycerol, insulin, alanine transaminase (ALT), and aspartate aminotransferase (AST) were evaluated. Liver histology was analyzed. Expression of ACC, PPAR-γ, ChREBP, SREBP-1 c, CPT-1, tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), NF-κB, interleukin 1 β (IL-1 β), and SIRT1 were evaluated by quantitative real-time reverse transcriptase PCR (qRT-PCR). Results The major finding of the present study was that RSV reduced body fat, total cholesterol, triacylglycerol, transaminases, and insulin plasma level. These results were accompanied with a significant reduction in TNF-α, IL-6, and NF-κB mRNA expression in the liver. Analyses of liver adipogenesis related genes indicated that ACC, PPAR-γ, and SREBP-1 mRNA expression were significantly suppressed in HFD + RSV mice. In addition, we observed increased expression of SIRT1 in the HFD + RSV group. Conclusions We observed that treatment with resveratrol improved lipid metabolism, and decreased NAFLD and pro-inflammatory profile in liver of mice with obesity-inducible diets. These data suggest an important clinical application of RSV in preventing liver diseases.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0899-9007eISSN: 1873-1244DOI: 10.1016/j.nut.2013.11.016Titel-ID: cdi_proquest_miscellaneous_1542648865
- Format
- –
- Schlagworte
- Adipocytes, Adipogenesis - genetics, Adipose Tissue - drug effects, Animals, Biological and medical sciences, Body weight, Cholesterol, Chronic illnesses, Cytokines - genetics, Cytokines - metabolism, Diabetes, Diet, Diet, High-Fat - adverse effects, Efficiency, Feeding. Feeding behavior, Food, Fundamental and applied biological sciences. Psychology, Gastroenterology and Hepatology, Gastroenterology. Liver. Pancreas. Abdomen, Gene expression, Histology, Inflammation, Inflammation - genetics, Inflammation - metabolism, Inflammation - prevention & control, Insulin, Insulin - blood, Lipids, Lipids - blood, Lipogenesis - drug effects, Liver, Liver - drug effects, Liver - metabolism, Liver diseases, Liver. Biliary tract. Portal circulation. Exocrine pancreas, Male, Mammals, Medical sciences, Metabolic diseases, Metabolic disorders, Mice, Mice, Inbred Strains, NF-kappa B - genetics, NF-kappa B - metabolism, Non-alcoholic Fatty Liver Disease - etiology, Non-alcoholic Fatty Liver Disease - metabolism, Non-alcoholic Fatty Liver Disease - prevention & control, Nonalcoholic fatty liver disease, Obesity, Obesity - metabolism, Other diseases. Semiology, Phytotherapy, Plant Extracts - pharmacology, Plant Extracts - therapeutic use, Resveratrol, RNA, Messenger - metabolism, Rodents, SIRT1, Software, Stilbenes - pharmacology, Stilbenes - therapeutic use, Studies, Transaminases - blood, Vertebrates: anatomy and physiology, studies on body, several organs or systems