Details

Autor(en) / Beteiligte

• Isik, Dilek U
• Aydemir, Ozge
• Kale, Yusuf
• Yucel, Husniye
• Bas, Ahmet Y
• Demirel, Nihal
• Arda, Nilufer
• Apaydin, Sema

Titel

Severe leukemoid reaction in a preterm infant with congenital cytomegalovirus infection

Ist Teil von

• Journal of pediatric hematology/oncology, 2014-07, Vol.36 (5), p.e310-e312

Ort / Verlag

United States

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Leukemoid reaction, defined as a total leukocyte count of >50,000/mm, is most commonly related to antenatal administration of steroids, infections, and transient myeloproliferative disorder of Down syndrome in newborns. Atypical presentations of viral infections can be a diagnostic challenge in the newborn period. Cytomegalovirus (CMV) infection causes a multisystem disease, and symptomatic infants generally present with intrauterine growth restriction, hepatosplenomegaly, cholestasis, rash, thrombocytopenia, and microcephaly. We present a case of a preterm infant with severe myeloid leukemoid reaction (leukocyte count >100,000/mm) at birth who was diagnosed with congenital CMV infection on the basis of CMV polymerase chain reaction results after the appearance of cholestasis, blueberry muffin rash, and hepatosplenomegaly.