Details

Autor(en) / Beteiligte

• You, Tongjian
• Wang, Xuewen
• Murphy, Karin M.
• Lyles, Mary F.
• Demons, Jamehl L.
• Yang, Rongze
• Gong, Da‐Wei
• Nicklas, Barbara J.

Titel

Regional adipose tissue hormone/cytokine production before and after weight loss in abdominally obese women

Ist Teil von

• Obesity (Silver Spring, Md.), 2014-07, Vol.22 (7), p.1679-1684

Ort / Verlag

United States: Blackwell Publishing Ltd

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective To compare the regional differences in subcutaneous adipose tissue hormone/cytokine production in abdominally obese women during weight loss. Methods Forty‐two abdominally obese, older women underwent a 20‐week weight loss intervention composed of hypocaloric diet with or without aerobic exercise (total energy expenditure: ∼2800 kcal/week). Subcutaneous (gluteal and abdominal) adipose tissue biopsies were conducted before and after the intervention. Adipose tissue gene expression and release of leptin, adiponectin, and interleukin 6 (IL‐6) were determined. Results The intervention resulted in significant weight loss (−10.1 ± 0.7 kg, P < 0.001). At baseline, gene expression of adiponectin were higher (P < 0.01), and gene expression and release of IL‐6 were lower (both P < 0.05) in abdominal than in gluteal adipose tissue. After intervention, leptin gene expression and release were lower in both gluteal and abdominal adipose tissue compared to baseline (P < 0.05‐0.01). Abdominal, but not gluteal, adipose tissue adiponectin gene expression and release increased after intervention (both P < 0.05). Conclusion A 20‐week weight loss program decreased leptin production in both gluteal and abdominal adipose tissue, but only increased adiponectin production from abdominal adipose tissue in obese women. This depot‐specific effect may be of importance for the treatment of health complications associated with abdominal adiposity.