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Lipid, protein and poly(NIPAM) coated mesoporous silica nanoparticles for biomedical applications
Ist Teil von
Advances in colloid and interface science, 2014-05, Vol.207, p.155-163
Ort / Verlag
Amsterdam: Elsevier B.V
Erscheinungsjahr
2014
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
In the past decade, mesoporous silica nanoparticles (MSNs) as nanocarriers have showed much potential in advanced nanomaterials due to their large surface area and pore volume. Especially, more and more MSNs based nanodevices have been designed as efficient drug delivery systems (DDSs) or biosensors. In this paper, lipid, protein and poly(NIPAM) coated MSNs are reviewed from the preparation, properties and their potential application. We also introduce the preparative methods including physical adsorption, covalent binding and self-assembly on the MSNs' surfaces. Furthermore, the interaction between the aimed cells and these molecular modified MSNs is discussed. We also demonstrate their typical applications, such as photodynamic therapy, bioimaging, controlled release and selective recognition in biomedical field.
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•Lipid, protein and poly(NIPAM) coated MSNs are reviewed.•Preparation, properties and their potential application are introduced.••Interaction between the cells and these molecular modified MSNs is discussed.••Some insights on future prospects of these composites are proposed.