Details

Autor(en) / Beteiligte

• Ciccia, Francesco
• Rizzo, Aroldo
• Alessandro, Riccardo
• Guggino, Giuliana
• Maugeri, Rosario
• Saieva, Laura
• Cannizzaro, Alessandra
• Giardina, AnnaRita
• De Leo, Giacomo
• Gerardo Iacopino, Domenico
• Triolo, Giovanni

Titel

Activated IL-22 pathway occurs in the muscle tissues of patients with polymyositis or dermatomyositis and is correlated with disease activity

Ist Teil von

• Rheumatology (Oxford, England), 2014-07, Vol.53 (7), p.1307-1312

Ort / Verlag

England

Erscheinungsjahr

2014

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• The aim of this study was to assess the expression of IL-22, IL-22 receptor 1 (IL-22R1), IL-22 binding protein (IL-22BP) and p-STAT3 in muscle tissue from patients with PM and DM. Levels of IL-22, IL-22R1, IL-22BP and STAT3 mRNA were quantified by RT-PCR. The expression of IL-22, IL-22R1, IL-22BP and p-STAT3 was also analysed using immunohistochemistry. Significant modulation of the IL-22 pathway was observed in inflammatory myopathic tissues. In particular, a significant overexpression of IL-22 at the protein but not the mRNA level was observed in PM/DM tissues and was correlated with myositis activity. IL-22R1 aberrant expression was also observed among infiltrating mononuclear cells and necrotic muscle cells. IL-22BP, which inhibits IL-22 signalling, was expressed only in some muscle fibres in PM/DM patients. Our findings indicate that the IL-22 pathway is activated in inflammatory myopathic tissues and may be involved in the induction of muscle inflammatory processes and muscle necrosis.