Biochemical and biophysical research communications, 1989-08, Vol.163 (1), p.627-634
1989
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Details
- Autor(en) / Beteiligte
- Titel
- Chromium (V) and hydroxyl radical formation during the glutathione reductase-catalyzed reduction of chromium (VI)
- Ist Teil von
- Biochemical and biophysical research communications, 1989-08, Vol.163 (1), p.627-634
- Ort / Verlag
- San Diego, CA: Elsevier Inc
- Erscheinungsjahr
- 1989
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- Electron spin resonance measurements provide evidence for the formation of long-lived Cr(V) intermediates in the reduction of Cr(VI) by glutathione reductase in the presence of NADPH and for the hydroxyl radical formation during the glutathione reductase catalyzed reduction of Cr(VI). Hydrogen peroxide suppresses Cr(V) and enhances the formation of hydroxyl radicals. Thus Cr(V) intermediates catalyze generation of hydroxyl radicals from hydrogen peroxide through a Fenton-like reaction. Thus the mechanism of Cr(VI) toxicity might involve the interaction between macromolecules and the hydroxyl radicals.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0006-291XeISSN: 1090-2104DOI: 10.1016/0006-291X(89)92183-9Titel-ID: cdi_proquest_miscellaneous_15376135
- Format
- –
- Schlagworte
- Analytical, structural and metabolic biochemistry, Animals, Biological and medical sciences, Cattle, chromium, Chromium - metabolism, Electron Spin Resonance Spectroscopy, Enzymes and enzyme inhibitors, formation, Free Radicals, Fundamental and applied biological sciences. Psychology, Glutathione Reductase - metabolism, Hydrogen Peroxide, Hydroxides - metabolism, In Vitro Techniques, NADP - metabolism, Oxidation-Reduction, Oxidoreductases