FEBS letters, 1988-08, Vol.236 (2), p.406-410
1988
Details
- Autor(en) / Beteiligte
- Titel
- Superoxide production from nonenzymatically glycated protein
- Ist Teil von
- FEBS letters, 1988-08, Vol.236 (2), p.406-410
- Ort / Verlag
- England: Elsevier B.V
- Erscheinungsjahr
- 1988
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Nonenzymatically glycated human serum albumin and glycated poly-lysine(Lys) in vitro brought about the reduction of nitroblue tetrazolium and ferricytochrome c at pH 9.06 and pH 7.8, respectively. This reduction was inhibited partially by superoxide dismutase (SOD). Glycated poly-Lys caused the oxidation of NADH in the presence of LDH at pH 7.0 which was completely inhibited by SOD. Glycated material was found to function both as a reductant and an oxidant. The reactivity of glycated material is discussed and a possible mechanism by which superoxide is produced is proposed. Results may give a clue to diabetic complications.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-5793eISSN: 1873-3468DOI: 10.1016/0014-5793(88)80066-8Titel-ID: cdi_proquest_miscellaneous_15357005
- Format
- –
- Schlagworte
- Albumin, Cytochrome c Group - metabolism, Glycosylation, HSA, human serum albumin, In Vitro Techniques, LDH, lactate dehydrogenase, Luminescence, NADH, nicotinamide adenine dinucleotide (reduced), Nitroblue Tetrazolium - metabolism, Nonenzymatic glycation, Oxidation-Reduction, Poly-lysine, Polylysine - metabolism, Serum Albumin - metabolism, Sulfhydryl Compounds, Superoxide, Superoxides - metabolism