Journal of antimicrobial chemotherapy, 2014-06, Vol.69 (6), p.1653-1659
2014
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- Autor(en) / Beteiligte
- Titel
- Involvement of the LPS-LPB-CD14-MD2-TLR4 inflammation pathway in HIV-1/HAART-associated lipodystrophy syndrome (HALS)
- Ist Teil von
- Journal of antimicrobial chemotherapy, 2014-06, Vol.69 (6), p.1653-1659
- Ort / Verlag
- England: Oxford University Press
- Erscheinungsjahr
- 2014
- Quelle
- Oxford Journals 2020 Medicine
- Beschreibungen/Notizen
- Objectives A relationship between obesity and intestinal bacterial translocation has been reported. Very little information is available with respect to the involvement of the bacterial translocation mechanistic pathway in HIV-1/highly active antiretroviral therapy (HAART)-associated lipodystrophy syndrome (HALS). We determined whether lipopolysaccharide (LPS)-binding protein (LBP), cluster of differentiation 14 (CD14), myeloid differentiation protein 2 (MD2) and toll-like receptor 4 (TLR4) single-nucleotide polymorphisms and LPS, LBP and soluble CD14 (sCD14) plasma levels are involved in HALS. Patients and methods This cross-sectional multicentre study involved 558 treated HIV-1-infected patients, 240 with overt HALS and 318 without HALS. Anthropometric, clinical, immunovirological and metabolic variables were determined. Polymorphisms were assessed by genotyping. Plasma levels were determined by ELISA in 163 patients (81 with HALS and 82 without HALS) whose stored plasma samples were available. Student's t-test, one-way ANOVA, two-way repeated measures ANOVA, the χ 2 test and Pearson and Spearman correlation analyses were carried out for statistical analysis. Results LBP rs2232582 T→C polymorphism was significantly associated with HALS (P = 0.01 and P = 0.048 for genotype and allele analyses, respectively). Plasma levels of LPS (P = 0.009) and LBP (P < 0.001) were significantly higher and sCD14 significantly lower (P < 0.001) in patients with HALS compared with subjects without HALS. LPS levels were independently predicted by triglycerides (P < 0.001) and hepatitis C virus (P = 0.038), LBP levels by HALS (P < 0.001) and sCD14 levels by age (P = 0.008), current HIV-1 viral load (P = 0.001) and protease inhibitor use (P = 0.018). Conclusions HALS is associated with LBP polymorphism and with higher bacterial translocation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0305-7453eISSN: 1460-2091DOI: 10.1093/jac/dku032Titel-ID: cdi_proquest_miscellaneous_1534854463
- Format
- –
- Schlagworte
- Acute-Phase Proteins - genetics, Acute-Phase Proteins - metabolism, Adult, Antiretroviral Therapy, Highly Active - adverse effects, Carrier Proteins - blood, Carrier Proteins - genetics, Carrier Proteins - metabolism, Case-Control Studies, CD4 Lymphocyte Count, Cross-Sectional Studies, Female, Hepatitis C virus, HIV Infections - complications, HIV Infections - drug therapy, HIV Infections - immunology, HIV Infections - virology, HIV-1, HIV-Associated Lipodystrophy Syndrome - diagnosis, HIV-Associated Lipodystrophy Syndrome - etiology, HIV-Associated Lipodystrophy Syndrome - metabolism, Human immunodeficiency virus 1, Humans, Inflammation, Lipopolysaccharide Receptors - blood, Lipopolysaccharide Receptors - genetics, Lipopolysaccharide Receptors - metabolism, Lipopolysaccharides - blood, Lipopolysaccharides - immunology, Lymphocyte Antigen 96 - genetics, Lymphocyte Antigen 96 - metabolism, Male, Membrane Glycoproteins - blood, Membrane Glycoproteins - genetics, Membrane Glycoproteins - metabolism, Metabolism, Middle Aged, Obesity, Polymorphism, Risk Factors, Signal Transduction, Statistical analysis, Tissues, Toll-Like Receptor 4 - genetics, Toll-Like Receptor 4 - metabolism, Variables, Viral Load