Science China. Life sciences, 2014-04, Vol.57 (4), p.432-444
2014
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- Autor(en) / Beteiligte
- Titel
- RNA-binding proteins in neurological diseases
- Ist Teil von
- Science China. Life sciences, 2014-04, Vol.57 (4), p.432-444
- Ort / Verlag
- Beijing: Science China Press
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Emerging studies support that RNA-binding proteins （RBPs） play critical roles in human biology and pathogenesis. RBPs are essential players in RNA processing and metabolism, including pre-mRNA splicing, polyadenylation, transport, surveillance, mRNA localization, mRNA stability control, translational control and editing of various types of RNAs. Aberrant expression of and mutations in RBP genes affect various steps of RNA processing, altering target gene function. RBPs have been associ- ated with various diseases, including neurological diseases. Here, we mainly focus on selected RNA-binding proteins including Nova-i/Nova-2, HuR/HuB/HuC/HuD, TDP-43, Fus, Rbfoxl/Rbfox2, QKI and FMRP, discussing their function and roles in human diseases.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1674-7305eISSN: 1869-1889DOI: 10.1007/s11427-014-4647-9Titel-ID: cdi_proquest_miscellaneous_1534846849
- Format
- –
- Schlagworte
- Animals, Antigens, Neoplasm - metabolism, Biomedical and Life Sciences, DNA-Binding Proteins - metabolism, ELAV Proteins - metabolism, Fragile X Mental Retardation Protein - metabolism, Gene Expression Profiling, Gene Expression Regulation, Humans, Life Sciences, Mice, mRNA, Mutation, Nerve Tissue Proteins - metabolism, Nervous System, Nervous System Diseases - metabolism, Nervous System Diseases - physiopathology, Review, RNA Processing, Post-Transcriptional, RNA Splicing Factors, RNA, Messenger - metabolism, RNA-Binding Protein FUS - metabolism, RNA-Binding Proteins - metabolism, RNA-Binding Proteins - physiology, RNA剪接, RNA加工, RNA结合蛋白, 人类生物学, 发病机制, 神经系统疾病, 稳定性控制