Details

Autor(en) / Beteiligte

• Eguchi, Hiroyuki
• Tsuruta, Munehisa
• Tani, Junichi
• Kuwahara, Reiichiro
• Hiromatsu, Yuji

Titel

Hypophosphatemic Osteomalacia Due to Drug-induced Fanconi's Syndrome Associated with Adefovir Dipivoxil Treatment for Hepatitis B

Ist Teil von

• Internal Medicine, 2014, Vol.53(3), pp.233-237

Ort / Verlag

Japan: The Japanese Society of Internal Medicine

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• We herein present the case of a 58-year-old Japanese man with Fanconi's syndrome with a 13-month history of bone pain in his ribs, hips, knees and ankles. He had been receiving low-dose adefovir dipivoxil (ADV) for the treatment of lamivudine-resistant chronic hepatitis B virus infection for eight years and subsequently developed severe hypophosphatemia and proximal renal tubule dysfunction. Magnetic resonance imaging showed multiple insufficiency fractures in the ribs, ileum, tibia and calcaneus. Whole-body bone scintigraphy demonstrated increased uptake in those areas. Following dose reduction of ADV and the administration of treatment with calcitriol and phosphates, the patient's serum phosphate level increased and his clinical symptoms improved. Physicians prescribing ADV should carefully monitor the renal function and serum phosphate level.