Details

Autor(en) / Beteiligte

• Langer, Eric S.
• Rader, Ronald A.

Titel

Single-use technologies in biopharmaceutical manufacturing: A 10-year review of trends and the future

Ist Teil von

• Engineering in life sciences, 2014-05, Vol.14 (3), p.238-243

Ort / Verlag

Blackwell Publishing Ltd

Erscheinungsjahr

2014

Quelle

Wiley Online Library

Beschreibungen/Notizen

• Single‐use bioprocessing equipment has made considerable progress in the past 10 years. These devices now dominate small‐ and mid‐scale bioprocessing and are starting to graduate to larger scale manufacturing. We now have nearly a decade of combined industry experience covering the benefits of single‐use vs. fixed stainless steel. Single‐use systems are generally recognized as enabling rapid setup of bioprocessing at multiple scales in the same manufacturing area. A decade ago there were significant unknowns and concerns about single‐use equipment. Today, these plastics and equipments have much improved, and include advanced design, multilayer laminated plastic bags, and other integrated technologies. This article reviews bioprocessing single‐use systems market characteristics and trends over the past decade and forecasts future developments. Much of this grounded and based on data from the annual survey of bioprocessing professionals conducted by BioPlan Associates, Inc., now in its 11th year. In addition to quantitative survey data, this annual report includes extensive discussion and external analysis of bioprocessing and related trends. This article also includes data from other primary research resources. Single‐use and modular systems are making capacity crunches increasingly unlikely; in fact, estimating current and projected industry capacity may become subjective and possibly irrelevant.