Details

Autor(en) / Beteiligte

• Aas, Monica
• Haukvik, Unn K.
• Djurovic, Srdjan
• Bergmann, Ørjan
• Athanasiu, Lavinia
• Tesli, Martin S.
• Hellvin, Tone
• Steen, Nils Eiel
• Agartz, Ingrid
• Lorentzen, Steinar
• Sundet, Kjetil
• Andreassen, Ole A.
• Melle, Ingrid

Titel

BDNF val66met modulates the association between childhood trauma, cognitive and brain abnormalities in psychoses

Ist Teil von

• Progress in neuro-psychopharmacology & biological psychiatry, 2013-10, Vol.46, p.181-188

Ort / Verlag

Amsterdam: Elsevier Inc

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• Brain derived neurotrophic factor (BDNF) is important for brain development and plasticity, and here we tested if the functional BDNF val66met variant modulates the association between high levels of childhood abuse, cognitive function, and brain abnormalities in psychoses. 249 patients with a broad DSM-IV schizophrenia spectrum disorder or bipolar disorder were consecutively recruited to the TOP research study (mean±age: 30.7±10.9; gender: 49% males). History of childhood trauma was obtained using the Childhood Trauma Questionnaire. Cognitive function was assessed through a standardized neuropsychological test battery. BDNF val66met was genotyped using standardized procedures. A sub-sample of n=106 Caucasians with a broad DSM-IV schizophrenia spectrum disorder or bipolar disorder (mean±age: 32.67±10.85; 49% males) had data on sMRI. Carriers of the Methionine (met) allele exposed to high level of childhood abuse demonstrated significantly poorer cognitive functioning compared to homozygotic Valine (val/val) carriers. Taking in consideration multiple testing, using a more conservative p value, this was still shown for physical abuse and emotional abuse, as well as a trend level for sexual abuse. Further, met carriers exposed to high level of childhood sexual abuse showed reduced right hippocampal volume (r2=0.43; p=0.008), and larger right and left lateral ventricles (r2=0.37; p=0.002, and r2=0.27; p=0.009, respectively). Our findings were independent of age, gender, diagnosis and intracranial volume. Our data demonstrate that in patients with psychoses, met carriers of the BDNF val66met with high level of childhood abuse have more cognitive and brain abnormalities than all other groups. •BDNF val66met modulates the association between trauma and function in psychoses.•Our data indicates gene x environmental interactions in psychoses.•Environment and genetic factors are important when targeting cognitive dysfunction.•Environment and genetic factors are important when targeting brain abnormalities.