Details

Autor(en) / Beteiligte

• Cullen, William R

Titel

Chemical Mechanism of Arsenic Biomethylation

Ist Teil von

• Chemical research in toxicology, 2014-04, Vol.27 (4), p.457-461

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• The bioconversion of inorganic arsenic to methylated metabolites affects the tissue distribution and retention of arsenic and its actions as a toxicant or carcinogen. Although enzymes that catalyze the methylation of arsenicals have been identified in all branches of the tree of life, fundamental questions persist about the chemical processes that underlie reactions that methylate this metalloid. Here, several reaction schemes for arsenic methylation are considered to encourage careful consideration of the chemical plausibility of these schemes.