Details

Autor(en) / Beteiligte

• Gong, Weijing
• Xiao, Di
• Ming, Guangfeng
• Yin, Jiye
• Zhou, Honghao
• Liu, Zhaoqian

Titel

Type 2 diabetes mellitus-related genetic polymorphisms in microRNAs and microRNA target sites (MicroRNAs中与2型糖尿病相关的基因多态性及microRNA靶位)

Ist Teil von

• Journal of diabetes, 2014-07, Vol.6 (4), p.279-289

Ort / Verlag

Australia: Blackwell Publishing Ltd

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Wiley-Blackwell Full Collection

Beschreibungen/Notizen

• MicroRNAs (miRNAs) are important endogenous regulators in eukaryotic gene expression and a broad range of biological processes. MiRNA‐related genetic variations have been proved to be associated with human diseases, such as type 2 diabetes mellitus (T2DM). Polymorphisms in miRNA genes (primary miRNAs, precursor miRNAs, mature miRNAs, and miRNA regulatory regions) may be involved in the development of T2DM by changing the expression and structure of miRNAs and target gene expression. Genetic polymorphisms of the 3′‐untranslated region (UTR) in miRNA target genes may destroy putative miRNA binding sites or create new miRNA binding sites, which affects the binding of UTRs with miRNAs, finally resulting in susceptibility to and development of T2DM. Therefore, focusing on studies into genetic polymorphisms in miRNAs or miRNA binding sites will help our understanding of the pathophysiology of T2DM development and lead to better health management. Herein, we review the association of genetic polymorphisms in miRNA and miRNA targets genes with T2DM development. 摘要 MicroRNAs（miRNAs）对于包括真核生物基因表达在内的多个生物学过程都有着重要的内源性调节作用。MiRNAs相关的基因变化已被证实与人类疾病如2型糖尿病相关。MiRNAs基因的多态性（初始miRNAs，前体miRNAs，成熟 miRNAs以及 miRNA 调节区域）可能通过改变miRNAs的表达和结构以及靶基因的表达参与了2型糖尿病的发生。MiRNA靶基因的3’‐非翻译区（3’‐untranslated region，UTR）的基因多态性可能破坏了预测的miRNA结合位点或创造了新的miRNA结合位点，从而影响了UTRs与miRNAs的结合，最终导致了对2型糖尿病的易感性和发展为2型糖尿病。因此，关注对miRNAs基因多态性或miRNAs结合位点的研究可以帮助我们理解2型糖尿病的发病机制，以更好的进行健康管理。在此我们回顾了miRNA基因多态性和miRNA靶基因与发生2型糖尿病的关系。