Details

Autor(en) / Beteiligte

• Dörr, Markus
• Meggers, Eric

Titel

Metal complexes as structural templates for targeting proteins

Ist Teil von

• Current opinion in chemical biology, 2014-04, Vol.19, p.76-81

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2014

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• •Recent advances in the design of protein binders based on inert metal complexes are reviewed.•Covered structural d6-metal complex templates include sandwich complexes, half-sandwich complexes and octahedral complexes.•Metal complexes complement the molecular diversity of organic chemistry by opening untapped chemical space. This article reviews recent advances in the design and discovery of inert metal complexes as protein binders. In these metal-based probes or drug candidates, the metal is supposed to exert a purely structural role by organizing the coordinating ligands in the three dimensional space to achieve a shape and functional group complementarity with the targeted protein pockets. Presented examples of sandwich, half-sandwich and octahedral d6-metal complexes reinforce previous perceptions that metal complexes are highly promising scaffolds for the design of small-molecule protein binders and complement the molecular diversity of organic chemistry by opening untapped chemical space.