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TNFα Secretion of Monocytes Exposed to Pulsed Radiofrequency Treatment: A Possible Working Mechanism of PRF Chronic Pain Management
Ist Teil von
Pain practice, 2014-06, Vol.14 (5), p.399-404
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2014
Link zum Volltext
Quelle
Wiley Blackwell Single Titles
Beschreibungen/Notizen
Pulsed radiofrequency treatment (PRF) is a promising new technique increasingly used in treatment of chronic pain. The molecular working mechanism of PRF is not exactly known and is currently being investigated. This study investigates a possible role of PRF‐induced modulation of TNFα secretion by differentiated monocytes in chronic pain management. The results show no significant PRF‐induced change in TNFα secretion of lipopolysaccharides (LPS)‐stimulated monocytes. However, PRF does significantly increase TNFα secretion of differentiated monocytes that have not been stimulated with LPS. This may indicate a possible role of PRF treatment in increasing TNFα production of nonstimulated monocytes. More research is needed to determine whether this is truly a part of the working mechanism of PRF in chronic pain management and which other factors are involved.