Details

Autor(en) / Beteiligte

• Fraser, CL
• Sarnacki, P

Titel

Na super(+)-K super(+)-ATPase pump function in rat brain synaptosomes is different in males and females

Ist Teil von

• American Journal of Physiology: Cell Physiology, 1989-01, Vol.257 (2), p.E284-E289

Erscheinungsjahr

1989

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• To understand the increased morbidity and mortality associated with acute hyponatremia in young women, the authors characterized the Na super(+)-K super(+)-adenosinetri-phosphatase (ATPase) pump in rat brain synaptosomes to determine if this adaptive mechanism was different between the sexes. Veratridine-stimulated sodium (Na super(+)) uptake was significantly greater in females than in males, suggesting either an increased rate of Na super(+) uptake and/or decreased extrusion of Na super(+) by the Na super(+)-K super(+)-ATPase pump in females. Transport evaluation of the Na super(+)-K super(+)-ATPase pump showed ouabain-sensitive K super(+) uptake in males to be significantly greater than in females and ouabain-sensitive Na super(+) uptake in inverted synaptosomes was 70% greater in males.