Details

Autor(en) / Beteiligte

• Albuquerque-Silva, Iolanda
• Vecellio, Laurent
• Durand, Marc
• Avet, John
• Le Pennec, Deborah
• de Monte, Michele
• Montharu, Jerome
• Diot, Patrice
• Cottier, Michele
• Dubois, Francis

Titel

Particle Deposition in a Child Respiratory Tract Model: In Vivo Regional Deposition of Fine and Ultrafine Aerosols in Baboons: e95456

Ist Teil von

• PloS one, 2014-04, Vol.9 (4)

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• To relate exposure to adverse health effects, it is necessary to know where particles in the submicron range deposit in the respiratory tract. The possibly higher vulnerability of children requires specific inhalation studies. However, radio-aerosol deposition experiments involving children are rare because of ethical restrictions related to radiation exposure. Thus, an in vivo study was conducted using three baboons as a child respiratory tract model to assess regional deposition patterns (thoracic region vs. extrathoracic region) of radioactive polydisperse aerosols ([d16-d84], equal to [0.15 mu m-0.5 mu m], [0.25 mu m-1 mu m], or [1 mu m-9 mu m]). Results clearly demonstrated that aerosol deposition within the thoracic region and the extrathoraic region varied substantially according to particle size. High deposition in the extrathoracic region was observed for the [1 mu m-9 mu m] aerosol (72% plus or minus 17%). The [0.15 mu m-0.5 mu m] aerosol was associated almost exclusively with thoracic region deposition (84% plus or minus 4%). Airborne particles in the range of [0.25 mu m-1 mu m] showed an intermediate deposition pattern, with 49% plus or minus 8% in the extrathoracic region and 51% plus or minus 8% in the thoracic region. Finally, comparison of baboon and human inhalation experiments for the [1 mu m-9 mu m] aerosol showed similar regional deposition, leading to the conclusion that regional deposition is species-independent for this airborne particle sizes.