Details

Autor(en) / Beteiligte

• Ahn, Jin Young, MD
• Song, Je Eun, MD
• Kim, Min Hyung, MD
• Choi, Heun, MD
• Kim, Jae Kyung, MD
• Ann, Hea Won, MD
• Kim, Jung Ho, MD
• Jeon, Yongduk, MD
• Jeong, Su Jin, MD, PhD
• Kim, Sun Bean, MD
• Ku, Nam Su, MD
• Han, Sang Hoon, MD, PhD
• Song, Young Goo, MD, PhD
• Yong, Dongeun, MD, PhD
• Lee, Kyungwon, MD, PhD
• Kim, June Myung, MD, PhD
• Choi, Jun Yong, MD, PhD

Titel

Risk factors for the acquisition of carbapenem-resistant Escherichia coli at a tertiary care center in South Korea: A matched case-control study

Ist Teil von

• American journal of infection control, 2014-06, Vol.42 (6), p.621-625

Ort / Verlag

New York, NY: Mosby, Inc

Erscheinungsjahr

2014

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background Carbapenem resistance among gram-negative bacilli is an emerging threat worldwide. The objective of this study was to identify risk factors for the acquisition of carbapenem-resistant Escherichia coli (CRE). Methods We conducted a matched case-control study comprising 57 cases of acquisition of CRE and 114 controls (1:2 matched) selected from patients with a culture of carbapenem-susceptible E coli between January 2006 and December 2010 at a 2000-bed tertiary care center in South Korea. Results On univariate analysis, previous use of carbapenem ( P  < .01), fluoroquinolone ( P  < .01), and glycopeptide ( P  < .01), as well as length of hospital stay ( P  < .05), were significantly associated with CRE acquisition. On multivariate analysis, previous use of carbapenem (odds ratio [OR], 4.56; 95% confidence interval [CI] 1.44-14.46; P  = .01) and previous use of fluoroquinolone (OR, 2.81; 95% CI, 1.14-6.99; P  = .03) were independent risk factors. Conclusions At this institute, the antibiotic selective pressure of carbapenems and fluoroquinolones was shown to be an important risk factor for the acquisition of CRE.