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Dixon-based MRI for assessment of muscle-fat content in phantoms, healthy volunteers and patients with achillodynia: comparison to visual assessment of calf muscle quality
Ist Teil von
European radiology, 2014-06, Vol.24 (6), p.1366-1375
Ort / Verlag
Berlin/Heidelberg: Springer Berlin Heidelberg
Erscheinungsjahr
2014
Quelle
MEDLINE
Beschreibungen/Notizen
Objectives
To quantify the muscle fat-content (MFC) in phantoms, volunteers and patients with achillodynia using two-point Dixon-based magnetic resonance imaging (2pt-MRI
DIXON
) in comparison to MR spectroscopy (MRS) and visual assessment of MFC.
Methods
Two-point Dixon-based MRI was used to measure the MFC of 15 phantoms containing 0-100 % fat-content and calf muscles in 30 patients (13 women; 57 ± 15 years) with achillodynia and in 20 volunteers (10 women; 30 ± 14 years) at 1.5 T. The accuracy of 2pt-MRI
DIXON
in quantification of MFC was assessed in vitro using phantoms and in vivo using MRS as the standard of reference. Fat-fractions derived from 2pt-MRI
DIXON
(FF
DIXON
) and MRS (FF
MRS
) were related to visual assessment of MFC (Goutallier grades 0–4) and Achilles-tendon quality (grade 0-4).
Results
Excellent linear correlation was demonstrated for FF
DIXON
with phantoms and with FF
MRS
in patients (
p
c
= 0.997/0.995;
p
< 0.001). FF
DIXON
of the gastrocnemius muscle was significantly higher (
p
= 0.002) in patients (7.0 % ± 4.7 %) compared with volunteers (3.6 % ± 0.7 %), whereas visual-grading showed no difference between both groups (
p
> 0.05). FF
MRS
and FF
DIXON
were significantly higher in subjects with (>grade 1) structural damage of the Achilles-tendon (
p
= 0.01).
Conclusions
Two-point Dixon-based MRI allows for accurate quantification of MFC, outperforming visual assessment of calf muscle fat. Structural damage of the Achilles tendon is associated with a significantly higher MFC.
Key points
•
Two-point Dixon-based MRI allows accurate quantification of muscular fat content (MFC).
•
Quantitative analysis outperforms visual analysis in the detection of elevated MFC.
•
Achillodynia results in an increased MFC of the gastrocnemius muscles.
•
Structural damage of the Achilles tendon further increases the MFC.