Details

Autor(en) / Beteiligte

• DE BERRANGER, E
• COUSIEN, A
• LUTZ, P
• YAKOUBEN, K
• DUHAMEL, A
• BRUNO, B
• MICHEL, G
• DALLE, J.-H
• PETIT, A
• PEFFAULT DE LATOUR, R
• GALAMBRUN, C
• BERTRAND, Y
• SALMON, A
• RIALLAND, F
• ROHRLICH, P.-S
• VANNIER, J.-P

Titel

Impact on long-term OS of conditioning regimen in allogeneic BMT for children with AML in first CR: TBI + CY versus BU + CY: a report from the Société Française de Greffe de Moelle et de Thérapie Cellulaire

Ist Teil von

• Bone marrow transplantation (Basingstoke), 2014-03, Vol.49 (3), p.382-388

Ort / Verlag

Basingstoke: Nature Publishing Group

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Allogeneic hematopoietic SCT (HSCT) appears to be an efficient tool to cure high-risk AML in first CR but the choice between BU-based or TBI-based conditioning regimens still remains controversial. In order to analyze the impact of conditioning regimen on long-term survival, we conducted a retrospective analysis from French registry data including all consecutive patients under 18 years old (n=226) from 1980 to 2004 transplanted for AML in CR1 from sibling (n=142) or matched unrelated donors and given either TBI-1200 cGy and CY 120 mg/kg (TBI-Cy, n=84) or BU 16 mg/kg and CY 200 mg/kg (BuCy200, n=142). Patient subgroups were comparable for all criteria except for median age at diagnosis and HSCT and for donor type. Both 5-year OS and disease-free survival (DFS) were significantly better in BuCy200 group (P=0.02 and 0.005, respectively). In multivariate analysis, both HLA matching and BuCy200 appeared as good prognostic factors for treatment-related mortality and DFS. Grade 2-4 acute GvHD and chronic GvHD rates were statistically higher in TBI-Cy group than in Bu-Cy200 one with a RR at 2 (P=0.002). In total, Bu-Cy200 conditioning regimen gives better outcome compared with TBI-Cy irrespective of the stem cell source and the donor type.