Bone marrow transplantation (Basingstoke), 2014-02, Vol.49 (2), p.241-247
2014
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- Autor(en) / Beteiligte
- Titel
- Donor TLR9 gene tagSNPs influence susceptibility to aGVHD and CMV reactivation in the allo-HSCT setting without polymorphisms in the TLR4 and NOD2 genes
- Ist Teil von
- Bone marrow transplantation (Basingstoke), 2014-02, Vol.49 (2), p.241-247
- Ort / Verlag
- Basingstoke: Nature Publishing Group
- Erscheinungsjahr
- 2014
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Owing to ethnicity of the population, those best confirmed polymorphisms in the TLR (toll-like receptor)4 and NOD2 genes with significantly prognostic impact on allogeneic hematopoietic SCT (allo-HSCT) seem to be more applicable to Europeans and are nonpolymorphic in the Asian population. The influence of innate immunity gene polymorphisms on the outcomes of allo-HSCT in those populations has been questioned. We evaluated the influence of 10 candidate single nucleotide polymorphisms (SNPs) in the TLR1, TLR2, TLR3, TLR8 and TLR9 genes on the outcomes of allo-HSCT in a Chinese population including 138 pairs of patients and unrelated donors and a second cohort of 102 pairs of patients and HLA-identical sibling donors. We found that two tagSNPs in the TLR9 gene in the donor side, +1174 A/G (rs352139) and +1635 C/T (rs352140), influenced the risk of acute GVHD (aGVHD) and CMV reactivation. Furthermore, the presence of the susceptible haplotype (A-C) in donor may be an informative predicator of worse OS at 5 years compared with those with the G-C and G-T haplotypes (58% vs 82.9%, P=0.024). Our data suggested an unrecognized association between donor TLR9 tagSNPs and the risk of HSCT-related complications in a population without polymorphisms in the TLR4 and NOD2 genes.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0268-3369eISSN: 1476-5365DOI: 10.1038/bmt.2013.160Titel-ID: cdi_proquest_miscellaneous_1524405748
- Format
- –
- Schlagworte
- Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy, Biological and medical sciences, Bone marrow, Bone marrow, stem cells transplantation. Graft versus host reaction, Complications, Cytomegalovirus, Female, Gene polymorphism, Genes, Genetic polymorphisms, Genetic susceptibility, Genotype, Graft versus host reaction, Graft vs Host Disease - etiology, Haplotypes, Hematopoietic Stem Cell Transplantation - adverse effects, Hematopoietic Stem Cell Transplantation - methods, Hematopoietic stem cells, Histocompatibility antigen HLA, Humans, Innate immunity, Male, Medical sciences, Minority & ethnic groups, NOD2 protein, Nod2 Signaling Adaptor Protein - genetics, Nod2 Signaling Adaptor Protein - metabolism, Nucleotides, Physiological aspects, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Population, Risk factors, Single-nucleotide polymorphism, Stem cell research, Stem cell transplantation, Tissue Donors, TLR1 protein, TLR2 protein, TLR3 protein, TLR4 protein, TLR9, TLR9 protein, Toll-Like Receptor 4 - genetics, Toll-Like Receptor 4 - metabolism, Toll-like receptors, Transfusions. Complications. Transfusion reactions. Cell and gene therapy, Transplantation, Transplantation Conditioning - adverse effects, Transplantation Conditioning - methods, Treatment Outcome