Details

Autor(en) / Beteiligte

• Shiang, R
• Murray, J C
• Morton, C C
• Buetow, KH
• Wasmuth, J J
• Olney, AH
• Sanger, W G
• Goldberger, G

Titel

Mapping of the human complement factor 1 gene to 4q25

Ist Teil von

• Genomics (San Diego, Calif.), 1989-01, Vol.4 (1), p.82-86

Erscheinungsjahr

1989

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• A detailed genetic and physical map of human complement factor I (IF) using somatic cell hybrids, in situ hybridization, and genetic linkage is reported. The gene has been localized to band 4q25. The order GC-INP10-ADH3-EGF-IF-IL2-MNS is proposed for genes on 4q on the basis of genetic and physical mapping techniques. A BclI polymorphism found with the IF probe demonstrated a maternal origin for a de novo deletion of chromosome 4 that was used in physically mapping the gene.