Details

Autor(en) / Beteiligte

• Goldenberg, Ilan
• Kutyifa, Valentina
• Klein, Helmut U
• Cannom, David S
• Brown, Mary W
• Dan, Ariela
• Daubert, James P
• Estes, N.A. Mark
• Foster, Elyse
• Greenberg, Henry
• Kautzner, Josef
• Klempfner, Robert
• Kuniss, Malte
• Merkely, Bela
• Pfeffer, Marc A
• Quesada, Aurelio
• Viskin, Sami
• McNitt, Scott
• Polonsky, Bronislava
• Ghanem, Ali
• Solomon, Scott D
• Wilber, David
• Zareba, Wojciech
• Moss, Arthur J

Titel

Survival with Cardiac-Resynchronization Therapy in Mild Heart Failure

Ist Teil von

• The New England journal of medicine, 2014-05, Vol.370 (18), p.1694-1701

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2014

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• In patients with reduced ejection fraction, mild heart failure, and prolonged QRS duration, CRT with a defibrillator improved survival, as compared with defibrillator therapy alone. The survival benefit was limited to patients with left bundle-branch block. The Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT) showed the safety and effectiveness of cardiac-resynchronization therapy (CRT) with a defibrillator (CRT-D) in patients with asymptomatic or mildly symptomatic heart failure, a reduced ejection fraction, and a prolonged QRS duration. 1 The study showed that treatment with CRT-D was associated with a 34% relative reduction in the risk of nonfatal heart-failure events or death from any cause, as compared with implantable cardioverter–defibrillator (ICD) therapy alone over a median follow-up period of 2.4 years. The benefit of CRT-D in the trial was primarily driven by a significant relative reduction of . . .