Details

Autor(en) / Beteiligte

• Ratnakar Reddy, K.
• Sambasiva Rao, P.
• Jitender Dev, G.
• Poornachandra, Y.
• Ganesh Kumar, C.
• Shanthan Rao, P.
• Narsaiah, B.

Titel

Synthesis of novel 1,2,3-triazole/isoxazole functionalized 2H-Chromene derivatives and their cytotoxic activity

Ist Teil von

• Bioorganic & medicinal chemistry letters, 2014-04, Vol.24 (7), p.1661-1663

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Novel 1,2,3-triazole 5a–q and isoxazole tagged 6a–i and 7a–g 2H-Chromene derivatives were prepared and screened for cytotoxic activity and promising compounds 5f, 5g, 5l, 5q have been identified. A series of novel 2-(1,2,3-triazolylmethoxy) 5a–q and isoxazole tagged 6a–g 2H-Chromene derivatives were prepared starting from salicylaldehyde and ethyl-4,4,4-trifluoroacetoacetate via cyclization to form ethyl 2-hydroxy-2-(trifluoromethyl)-2H-Chromene-3-carboxylate 3. Compound 3 on reaction with propargyl bromide resulted compound 4 and was independently reacted with aryl/alkyl azides and aryl aldoximes obtained 2-(1,2,3-triazolylmethoxy) and isoxazole tagged 2H-Chromene derivatives 5a–q, 6a–i, respectively. Compounds 6 were further hydrolysed to acid derivatives 7a–g. All the products 5a–q, 6a–i, 7a–g were screened for cytotoxic activity against four human cancer cell lines and among all the compounds, 5f, 5g, 5l, 5q showed promising activity at <20μM concentration.