Vaccine, 2013-12, Vol.31 (49), p.5915-5922
2013
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Neurovirulent flavivirus can be attenuated in mice by incorporation of neuron-specific microRNA recognition elements into viral genome
- Ist Teil von
- Vaccine, 2013-12, Vol.31 (49), p.5915-5922
- Ort / Verlag
- Kidlington: Elsevier Ltd
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights ▶ Cellular microRNA inhibits expression of flaviviral mRNA lacking poly(A). ▶ Brain neurons are major targets of infection by neurotropic flaviviruses. ▶ Inclusion of engineered miRNA recognition elements into genome provides a rational design for safer flavivirus vaccines.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0264-410XeISSN: 1873-2518DOI: 10.1016/j.vaccine.2011.09.102Titel-ID: cdi_proquest_miscellaneous_1520379052
- Format
- –
- Schlagworte
- 3' Untranslated Regions, Allergy and Immunology, Animals, Applied microbiology, Biological and medical sciences, Biosafety, Brain research, Cell Line, Central nervous system, encephalitis, Encephalitis Virus, Japanese - genetics, Encephalitis Virus, Japanese - pathogenicity, Encephalitis Virus, Japanese - physiology, engineering, Experiments, Flavivirus, Flavivirus Infections - immunology, Flavivirus Infections - virology, Flavivirus vaccine, Fundamental and applied biological sciences. Psychology, Gene expression, Gene Silencing, genome, Genome, Viral, Genomes, immunity, Immunization, Infections, Japanese encephalitis virus, Laboratory animals, Male, Medical research, messenger RNA, Methods, Mice, Mice, Inbred ICR, Microbiology, MicroRNA, MicroRNAs - genetics, Miscellaneous, mutants, Neurons, Neurons - virology, Pathogenesis, RNA, Messenger - genetics, RNA, Viral - genetics, Rodents, tail, tissue tropism, Tissue-specific suppression, Vaccines, Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects), Vaccines, Attenuated - immunology, Vector-borne diseases, Viral Tropism, Viral Vaccines - immunology, Virology, Virus Replication, viruses