Clinical infectious diseases, 2014-05, Vol.58 (10), p.1439-1448
2014
Details
- Autor(en) / Beteiligte
- Titel
- Treatment of Multidrug-Resistant Gram-Negative Infections in Children
- Ist Teil von
- Clinical infectious diseases, 2014-05, Vol.58 (10), p.1439-1448
- Ort / Verlag
- Oxford: OXFORD UNIVERSITY PRESS
- Erscheinungsjahr
- 2014
- Link zum Volltext
- Quelle
- Oxford Journals 2020 Medicine
- Beschreibungen/Notizen
- Antibiotic resistance in conjunction with the erosion of the drug development pipeline may lead us into a bleak future, a "post-antibiotic era." Because of a shortage of studies addressing treatment options for multidrugresistant Gram-negative (MDRGN) infections in children, data must be extrapolated from the adult literature. However, even adult studies are limited by significant methodological flaws. We are in urgent need of pediatric specific pharmacokinetic/pharmacodynamic data for agents with activity against MDRGN infections as well as improved clinical outcomes studies. For the time being, we must rely on in vitro studies, observational data, and clinical experience to guide our therapeutic decisions. In this review, we discuss treatment considerations for infections caused by extended-spectrum β-lactamase–producing organisms, AmpC β-lactamase–producing organisms, carbapenem-resistant Enterobacteriaceae, carbapenem-resistant Pseudomonas aeruginosa, and carbapenem-resistant Acinetobacter baumannii in the pediatric population.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1058-4838eISSN: 1537-6591DOI: 10.1093/cid/ciu069Titel-ID: cdi_proquest_miscellaneous_1520112184
- Format
- –
- Schlagworte
- Acinetobacter baumannii - drug effects, Adult, Aminoglycosides, Anti-Bacterial Agents - pharmacology, Anti-Bacterial Agents - therapeutic use, Bacterial Proteins - metabolism, beta-Lactamases - metabolism, Biological and medical sciences, Carbapenems, Carbapenems - pharmacology, Carbapenems - therapeutic use, Child, Children & youth, Dosage, Drug Resistance, Multiple, Bacterial, Enterobacter, Enterobacteriaceae, Enterobacteriaceae - drug effects, Escherichia coli, Fluoroquinolones, Gram-negative bacteria, Gram-Negative Bacteria - drug effects, Gram-Negative Bacteria - enzymology, Gram-Negative Bacterial Infections - drug therapy, Gram-Negative Bacterial Infections - microbiology, Humans, Infections, Infectious diseases, Klebsiella pneumoniae, Medical sciences, Medical treatment, Microbial Sensitivity Tests, Multidrug resistant organisms, Pediatrics, Pseudomonas aeruginosa - drug effects, REVIEWS OF ANTI-INFECTIVE AGENTS