Details

Autor(en) / Beteiligte

• Nezhat, Farr Reza
• Pejovic, Tanja
• Reis, Fernando M
• Guo, Sun-Wei

Titel

The Link Between Endometriosis and Ovarian Cancer: Clinical Implications

Ist Teil von

• International journal of gynecological cancer, 2014-05, Vol.24 (4), p.623-628

Ort / Verlag

England: by the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• OBJECTIVESThe objectives of this study were to evaluate the current evidence of the association of endometriosis and subsequent carcinoma of the ovary and to contextualize this evidence into daily practice issues. METHODSThis study is a critical review of observational and in vitro studies. RESULTSAlthough the lifetime risk for ovarian cancer is low in general population and remains low in the broad spectrum of endometriosis, there may be clusters of individuals at higher risk of oncogenesis, whose identification would allow individualized surveillance and prophylactic interventions. Prevalence studies show that specific subtypes of ovarian cancer predominate in women with endometriosis. This has been validated in pathogenetic, genomic, immunobiologic, and hormonal studies. CONCLUSIONSTaken together, these data provide a strong rationale for identifying, monitoring, counseling, and treating women with endometriosis who are at highest risk for cancer conversion.