Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
[...]a low CFR does not necessarily reflect a reduction of maximum flow, but it can be caused by an abnormally elevated resting flow in the face of a normal hyperaemic flow.w3 CMD is found both in primary and secondary cardiomyopathies with very important prognostic implications. Cardiomyopathies are grouped into specific morphological and functional phenotypes; each phenotype is then sub-classified into familial and non-familial forms. 3 Prompted by recent work by Camici et al on CMD in left ventricular (LV) hypertrophy, both of primary and secondary aetiology, we decided to perform a more focused review on myocardial ischaemia in primary cardiomyopathies.w4 Hypertrophic cardiomyopathy HCM is the most common genetic heart disease, with prevalence in the general population of 1:500, and characterised by extreme heterogeneity with regard to phenotypic expression, pathophysiology, and clinical course. 4 w5-w8 HCM is the most common cause of sudden cardiac death in the young, but also a major cause of heart failure and disability at any age.w9-w12 Myocardial ischaemia due to severe CMD is an established pathophysiologic feature in HCM ( table 1 ) and may be associated with important disease related complications that have an impact on the clinical outcome, including adverse LV remodelling and systolic dysfunction ( figure 1 ).