Details

Autor(en) / Beteiligte

• Devereaux, P.J
• Mrkobrada, Marko
• Sessler, Daniel I
• Leslie, Kate
• Alonso-Coello, Pablo
• Kurz, Andrea
• Villar, Juan Carlos
• Sigamani, Alben
• Biccard, Bruce M
• Meyhoff, Christian S
• Parlow, Joel L
• Guyatt, Gordon
• Robinson, Andrea
• Garg, Amit X
• Rodseth, Reitze N
• Botto, Fernando
• Lurati Buse, Giovanna
• Xavier, Denis
• Chan, Matthew T.V
• Tiboni, Maria
• Cook, Deborah
• Kumar, Priya A
• Forget, Patrice
• Malaga, German
• Fleischmann, Edith
• Amir, Mohammed
• Eikelboom, John
• Mizera, Richard
• Torres, David
• Wang, C.Y
• VanHelder, Tomas
• Paniagua, Pilar
• Berwanger, Otavio
• Srinathan, Sadeesh
• Graham, Michelle
• Pasin, Laura
• Le Manach, Yannick
• Gao, Peggy
• Pogue, Janice
• Whitlock, Richard
• Lamy, André
• Kearon, Clive
• Baigent, Colin
• Chow, Clara
• Pettit, Shirley
• Chrolavicius, Susan
• Yusuf, Salim

Titel

Aspirin in Patients Undergoing Noncardiac Surgery

Ist Teil von

• The New England journal of medicine, 2014-04, Vol.370 (16), p.1494-1503

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• In this trial, administering aspirin before surgery and during the early postsurgical period did not affect the rate of death or nonfatal MI but increased the risk of major bleeding. This was true in patients who had not been taking aspirin and in those on a long-term aspirin regimen. Myocardial infarction is the most common major vascular complication that occurs after noncardiac surgery. 1 – 3 Noncardiac surgery is associated with platelet activation, 4 and coronary-artery thrombus may be a mechanism of perioperative myocardial infarction. 5 , 6 Aspirin inhibits platelet aggregation, 7 and the perioperative administration of aspirin may prevent major vascular complications by inhibiting thrombus formation. 8 In a meta-analysis of data from large, randomized trials involving more than 110,000 patients who were not undergoing surgery, the use of aspirin was shown to prevent myocardial infarction and major vascular events. 9 High-dose aspirin has not been shown to be superior to low-dose aspirin in preventing . . .