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Phase I/II trial of a replication-deficient trivalent influenza virus vaccine lacking NS1
Vaccine, 2013-12, Vol.31 (52), p.6194-6200
2013

Details

Autor(en) / Beteiligte
Titel
Phase I/II trial of a replication-deficient trivalent influenza virus vaccine lacking NS1
Ist Teil von
  • Vaccine, 2013-12, Vol.31 (52), p.6194-6200
Ort / Verlag
Kidlington: Elsevier Ltd
Erscheinungsjahr
2013
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
  • Highlights • We performed the first in man study with a live replication-deficient delNS1-trivalent vaccine. • Significant antibody titers to influenza strains contained in the vaccine were induced. • Seroconversion occurred most frequently in participants who were seronegative before vaccination. • A single intranasal dose was well tolerated and safe in healthy male and female participants. • No vaccine virus could be re-isolated in volunteers after immunization.
Sprache
Englisch
Identifikatoren
ISSN: 0264-410X
eISSN: 1873-2518
DOI: 10.1016/j.vaccine.2013.10.061
Titel-ID: cdi_proquest_miscellaneous_1516750189
Format
–
Schlagworte
Administration, Intranasal, Adolescent, Adult, adults, Allergy and Immunology, antibodies, Antibodies, Viral - blood, Applied microbiology, Biological and medical sciences, Drug-Related Side Effects and Adverse Reactions - epidemiology, Drug-Related Side Effects and Adverse Reactions - pathology, Female, Fundamental and applied biological sciences. Psychology, Good Manufacturing Practice, headache, Healthy Volunteers, Humans, immune response, Immunization, Influenza, Influenza A Virus, H1N1 Subtype - genetics, Influenza A Virus, H1N1 Subtype - immunology, Influenza A Virus, H3N2 Subtype - genetics, Influenza A Virus, H3N2 Subtype - immunology, Influenza B virus - genetics, Influenza B virus - immunology, Influenza Vaccines - administration & dosage, Influenza Vaccines - adverse effects, Influenza Vaccines - immunology, Influenza virus, Intranasal, Live-attenuated, Male, Microbiology, Miscellaneous, NS1, Orthomyxoviridae, Placebos - administration & dosage, Reverse genetics, seroprevalence, Trivalent, vaccination, Vaccines, Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects), Vaccines, Attenuated - administration & dosage, Vaccines, Attenuated - immunology, Viral infections, Viral Nonstructural Proteins - deficiency, Virology

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