Vaccine, 2013-11, Vol.31 (47), p.5585-5593
2013
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- Autor(en) / Beteiligte
- Titel
- Expression of human CEACAM1 in transgenic mice limits the Opa-specific immune response against meningococcal outer membrane vesicles
- Ist Teil von
- Vaccine, 2013-11, Vol.31 (47), p.5585-5593
- Ort / Verlag
- Kidlington: Elsevier Ltd
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • We developed a human-CEACAM1 transgenic mouse model. • We tested the impact of Opa proteins in outer membrane vesicles in vivo. • Opa does not influence the overall immune response against outer membrane vesicles. • The expression of human CEACAM1 results in reduced Opa specific antibodies.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0264-410XeISSN: 1873-2518DOI: 10.1016/j.vaccine.2013.07.069Titel-ID: cdi_proquest_miscellaneous_1516745613
- Format
- –
- Schlagworte
- Allergy and Immunology, animal models, Animals, antibacterial properties, antibodies, Antibodies, Bacterial - blood, Antigens, Antigens, CD - biosynthesis, Antigens, CD - genetics, Applied microbiology, bacterial adhesion, Bacterial Outer Membrane Proteins - immunology, Bacteriology, Biological and medical sciences, Blood Bactericidal Activity, CD4-positive T-lymphocytes, CEACAM1, Cell Adhesion Molecules - biosynthesis, Cell Adhesion Molecules - genetics, Cell growth, cell proliferation, Cell-Derived Microparticles - immunology, Cloning, Deoxyribonucleic acid, DNA, Enzyme-Linked Immunosorbent Assay, Experiments, Fundamental and applied biological sciences. Psychology, Gene Expression, genes, Humans, Immune response, Immune system, Immunization, immunoglobulin G, Immunoglobulin G - blood, Lymphocytes, Meningitis, Meningococcal vaccine, Meningococcal Vaccines - administration & dosage, Meningococcal Vaccines - immunology, Mice, Mice, Inbred C57BL, Mice, Transgenic, Microbiology, Miscellaneous, Neisseria meningitidis, OMV, Opa, Opacity, Opacity proteins, outer membrane proteins, Outer membrane vesicles, Proteins, receptors, Rodents, Studies, transgenic animals, Vaccination - methods, Vaccines, Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)