Vaccine, 2012-04, Vol.30, p.A44-A51
2012
Details
- Autor(en) / Beteiligte
- Titel
- Efficacy and immunogenicity of two or three dose rotavirus-vaccine regimen in South African children over two consecutive rotavirus-seasons: A randomized, double-blind, placebo-controlled trial
- Ist Teil von
- Vaccine, 2012-04, Vol.30, p.A44-A51
- Ort / Verlag
- Netherlands: Elsevier Ltd
- Erscheinungsjahr
- 2012
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights ► Rotarix associated with 59% reductions in severe gastroenteritis over 2 consecutive rotavirus seasons in South Africa. ► 3-dose Rotarix schedule was associated with the trend of being more immunogenic than a 2-doses. ► 3-dose Rotarix schedule was associated with higher efficacy estimate over two seasons than a 2-doses. ► The optimal dosing schedule of Rotarix in providing long-term protection in African children needs to be explored.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0264-410XeISSN: 1873-2518DOI: 10.1016/j.vaccine.2011.08.080Titel-ID: cdi_proquest_miscellaneous_1516744018
- Format
- –
- Schlagworte
- Administration, Oral, Africa, Africans, Allergy and Immunology, children, cohort studies, confidence interval, Diarrhea, Double-Blind Method, Female, gastroenteritis, Gastroenteritis - epidemiology, Gastroenteritis - pathology, Gastroenteritis - prevention & control, Gastroenteritis - virology, Human rotavirus, Humans, immune response, industrialization, Infant, infants, Male, monitoring, Placebos - administration & dosage, Prospective Studies, Rotavirus, Rotavirus Infections - epidemiology, Rotavirus Infections - pathology, Rotavirus Infections - prevention & control, Rotavirus Infections - virology, Rotavirus Vaccines - administration & dosage, Rotavirus Vaccines - immunology, Severity of Illness Index, South Africa - epidemiology, Vaccination - methods, Vaccine efficacy, vaccines, Vaccines, Attenuated - administration & dosage, Vaccines, Attenuated - immunology