Details

Autor(en) / Beteiligte

• Marx, Alexander
• Ströbel, Philipp
• Badve, Sunil S.
• Chalabreysse, Lara
• Chan, John K.C.
• Chen, Gang
• de Leval, Laurence
• Detterbeck, Frank
• Girard, Nicolas
• Huang, Jim
• Kurrer, Michael O.
• Lauriola, Libero
• Marino, Mirella
• Matsuno, Yoshihiro
• Molina, Thierry Jo
• Mukai, Kiyoshi
• Nicholson, Andrew G.
• Nonaka, Daisuke
• Rieker, Ralf
• Rosai, Juan
• Ruffini, Enrico
• Travis, William D.

Titel

ITMIG Consensus Statement on the Use of the WHO Histological Classification of Thymoma and Thymic Carcinoma: Refined Definitions, Histological Criteria, and Reporting

Ist Teil von

• Journal of thoracic oncology, 2014-05, Vol.9 (5), p.596-611

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• The 2004 version of the World Health Organization classification subdivides thymic epithelial tumors into A, AB, B1, B2, and B3 (and rare other) thymomas and thymic carcinomas (TC). Due to a morphological continuum between some thymoma subtypes and some morphological overlap between thymomas and TC, a variable proportion of cases may pose problems in classification, contributing to the poor interobserver reproducibility in some studies. To overcome this problem, hematoxylin-eosin–stained and immunohistochemically processed sections of prototypic, “borderland,” and “combined” thymomas and TC (n = 72) were studied by 18 pathologists at an international consensus slide workshop supported by the International Thymic Malignancy Interest Group. Consensus was achieved on refined criteria for decision making at the A/AB borderland, the distinction between B1, B2, and B3 thymomas and the separation of B3 thymomas from TCs. “Atypical type A thymoma” is tentatively proposed as a new type A thymoma variant. New reporting strategies for tumors with more than one histological pattern are proposed. These guidelines can set the stage for reproducibility studies and the design of a clinically meaningful grading system for thymic epithelial tumors.