Details

Autor(en) / Beteiligte

• Wang, Ze-Mu, M.D
• Zhao, Di, M.D
• Nie, Zhen-Lin, M.D
• Zhao, Huan, M.D
• Zhou, Bo, M.D
• Gao, Wei, M.D
• Wang, Lian-Sheng, M.D., Ph.D
• Yang, Zhi-Jian, M.D., Ph.D

Titel

Flavonol intake and stroke risk: A meta-analysis of cohort studies

Ist Teil von

• Nutrition (Burbank, Los Angeles County, Calif.), 2014-05, Vol.30 (5), p.518-523

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Objective Epidemiologic findings are inconsistent regarding the association between flavonol intake and the risk for stroke. The aim of this study was to determine whether an association exists between them in observational studies. Methods We searched the PubMed and EMBASE databases for studies conducted from 1966 to August 2013. Prospective cohort studies that provided relative risk (RR) estimates with 95% confidence intervals (CIs) for the association between flavonol intake and risk for stroke were included. A random effects model was used to combine study-specific risk estimates. Results The meta-analysis included eight studies, with 5228 stroke cases among 280 174 participants. The summary RR indicated a significant association between highest flavonol intake and reduced risk for stroke (summary RR, 0.86; 95% CI, 0.75–0.99). Furthermore, an increase in flavonol intake of 20 mg/d was associated with a 14% decrease in the risk for developing stroke (summary RR, 0.86; 95% CI, 0.77–0.96). Subgroup analyses suggested a significant inverse association between highest flavonol intake and stroke risk among men (summary RR, 0.74; 95% CI, 0.56–0.97) but not women (summary RR, 0.99; 95% CI, 0.85–1.16). Conclusions Higher dietary flavonol intake is associated with a reduced risk for stroke, especially among men. Our results support recommendations for higher consumption of flavonol-rich foods to prevent stroke.