Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Multitarget Stool DNA Testing for Colorectal-Cancer Screening
Ist Teil von
The New England journal of medicine, 2014-04, Vol.370 (14), p.1287-1297
Ort / Verlag
Waltham, MA: Massachusetts Medical Society
Erscheinungsjahr
2014
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
A stool test that measures mutant KRAS, abnormal gene methylation, and hemoglobin detected significantly more colorectal cancers than a commercial fecal immunochemical test (FIT) but had more false positive results.
Colorectal cancer is a major cause of death and disease among men and women in the United States.
1
The underlying neoplastic processes of colorectal carcinogenesis lend themselves to screening.
2
Evidence supports and guidelines endorse several tests and strategies,
3
–
5
and screening for colorectal cancer has been found to be cost-effective.
5
–
7
Despite the supporting evidence, recommendations, and availability of several screening tests, a substantial proportion of the U.S. population is not up to date with screening.
8
A simple, noninvasive test with high sensitivity for both colorectal cancer and advanced precancerous lesions might increase uptake and adherence rates, which could improve . . .