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Effect of formalin fixation on biexponential modeling of diffusion decay in prostate tissue
Magnetic resonance in medicine, 2013-10, Vol.70 (4), p.1160-1166
Bourne, Roger
Bongers, Andre
Charles, Ned
Power, Carl
Sved, Paul
Watson, Geoffrey
2013
Details
Autor(en) / Beteiligte
Bourne, Roger
Bongers, Andre
Charles, Ned
Power, Carl
Sved, Paul
Watson, Geoffrey
Titel
Effect of formalin fixation on biexponential modeling of diffusion decay in prostate tissue
Ist Teil von
Magnetic resonance in medicine, 2013-10, Vol.70 (4), p.1160-1166
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2013
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Purpose To evaluate the effect of formalin fixation on biexponential modeling of diffusion decay in prostate tissue. Methods Three whole prostate specimens were imaged unfixed immediately postsurgery, and again after formalin fixation. Diffusion‐weighted imaging was performed over an extended range of b‐values and a biexponential model fitted to the signal decay curves. Results Tissue fixation resulted in a 35%, 20%, and 20% reduction in mean apparent diffusion coefficient of the higher diffusivity fit component for the three organs, respectively, and a 64%, 57%, and 45% reduction in mean apparent diffusion coefficient of the lower diffusivity component. The mean signal fraction of the higher diffusivity component was increased by 23%, 5%, and 1%, respectively. The effect of fixation did not appear to vary according to tissue type or glandular zone. Conclusion Formalin fixed tissue appears to provide a stable model for detailed investigation of the microscopic biophysical basis of diffusion phenomena observed in vivo. Diffusivity changes that result from fixation may provide information about the microscopic environments of the biexponential components. Magn Reson Med, 70:1160–1166, 2013. © 2012 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0740-3194
eISSN: 1522-2594
DOI: 10.1002/mrm.24549
Titel-ID: cdi_proquest_miscellaneous_1508678866
Format
–
Schlagworte
biexponential
,
Computer Simulation
,
diffusion decay
,
fixation
,
Fixatives - chemistry
,
Formaldehyde - chemistry
,
formalin
,
Humans
,
Image Interpretation, Computer-Assisted - methods
,
Male
,
Models, Biological
,
multiexponential
,
prostate
,
Prostate - chemistry
,
Prostate - pathology
,
Reproducibility of Results
,
Sensitivity and Specificity
,
Tissue Fixation - methods
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