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Figures of merit are introduced for estimation of achievable resolution of surface plasmon (SP) sensors by modulation type. The resolution of SP sensors in the Kretschmann’s geometry is estimated by numerical simulation for combinations of silver (Ag), copper (Cu), aluminum (Al), chromium, and titanium layers with a gold (Au) layer in the ultraviolet (UV), visible, and infrared (IR) regions in cases of detecting the change of the refractive index of water and the presence of an adsorption layer in water. SP biosensors with angular modulation based on Al exhibit low resolution in the UV region; Ag, Au, and Cu biosensors show best resolution in the visible region. Biosensors with intensity modulation demonstrate high performance in the near IR by Ag, Au, and Cu metals, and in the UV by Al.